Membership Renewal and Membership Application
Dear pancreatobiliary pathology enthusiasts. We would like to ask all members to update their information and renew their memberships. To renew your membership please click here.
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If you want to apply for membership please click here.
If you experience any problems please contact us.
A 2-year-old-baby presented as a transfer from an outside hospital (OSH) due to concerns for possible acute cholecystitis. The patient has a history of abdominal pain for the last 2 weeks. The laboratory tests from the OSH were notable for leukocytosis. An abdominal CT scan showed a thickened gallbladder wall with numerous polypoid, non-mobile lesions. Eventually, the patient underwent laparoscopic cholecystectomy.
See figures and answer here: Case 4: Quarter 3, 2021
2021 PBPath Business Meeting agenda/minutes
Pancreatobiliary Pathology Society Members,
Alas, we will not be able to meet in person this year, therefore please find attached the 2021 Pancreatobiliary Pathology Society (PBPS) Annual Business meeting agenda/minutes for your review to learn what PBPS has accomplished: PBPath Business Meeting 2021
1. Listen to our PBPS Companion meeting speakers, submit your questions and attend the LIVE Question and Answer on Tuesday March 16, 2021 11-11:30 AM PST
2. Vote for our new member before March 20, 2021 (will only take 1 minute) https://www.surveymonkey.com/r/7PWVKV5
Can’t wait to see all of you in person next year!
Grace E. Kim
Pancreatobiliary Pathology Society Secretary/Treasurer
A 50-year-old woman with no significant past medical history presented with abdominal pain and a syncopal episode. Abdominal MRI showed a multicystic mass with a significant solid component in the pancreatic tail, measuring 2.2 cm in the greatest dimension. A fine-needle biopsy of the lesion was performed.
See figures and answer here: Case 3: Quarter 2, 2021
Pancreatobiliary Pathology Society Companion Meeting USCAP 2021
Rondell Graham, MBBS, Mayo Clinic (Moderator)
Michelle D. Reid, MD, MSc, Emory University Hospital (Moderator)
Barbara A. Centeno, MD, H. Lee Moffitt Cancer Center & Research Institute
Vikram Deshpande, MBBS, MD, Massachusetts General Hospital, Harvard Medical School
Günter Klöppel, MD, PhD, Technical University of Munich
Giuseppe Zamboni, MD, University of Verona
Inflammatory Conditions of the Pancreatobiliary Tree
This session includes 1.5 hours of on-demand educational content. This content can be viewed starting March 1. There will also be a live 30-minute Q&A session with the faculty on Tuesday, March 16, from 11:00 AM – 11:30 AM Pacific Time.
Chronic pancreatitis is a complex inflammatory process with rising incidence and prevalence, and no curative treatment for frequently intractable chronic pain. Despite advances in the field, challenges remain in the radiologic, endoscopic and histologic diagnosis, and the distinction of pancreatitis from cancer. Although some specific pathologic subtypes of pancreatitis have been described and characterized in the past decade, many pathologists are still unaware of their existence, clinicopathologic characteristics, management and genetic implications. Pathologists also struggle with formulating diagnoses, reporting terminology, and determining etiology, particularly on small biopsies, fine needle aspirations and bile duct brushings. In the past year alone numerous multidisciplinary international, consensus guideline manuscripts have made new recommendations regarding risk factors, etiology, management (endoscopic, surgical/non-surgical), and histopathology of chronic pancreatitis. The latter was aimed at clarifying the pathologist’s role in diagnosis, histopathologic criteria, standardizing reports, and limiting confusion in reporting and the literature. The Pancreatobiliary Pathology Society executive committee determined the theme, titles, content and speakers for this year’s companion meeting, with a mission to educate surgical and Cytopathologists on recent advances in inflammatory conditions of the pancreatobiliary tree. This year’s meeting will provide a 360-degree expert analysis and update on acute and chronic inflammatory conditions of pancreatobiliary tree, including specific entities acute/alcoholic pancreatitis (Dr. Günter Klöppel), paraduodenal pancreatitis (Dr. Giuseppe Zamboni), IgG4-related (autoimmune) pancreatitis (Dr. Vikram Deshpande), and the cytopathology of inflammatory lesions of the pancreatobiliary tree (Dr. Barbara Centeno).
The program can be accessed by USCAP attendees here:
Continuing Medical Education
This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of The United States and Canadian Academy of Pathology and the Pancreatobiliary Pathology Society. The United States and Canadian Academy of Pathology is accredited by the ACCME to provide continuing medical education for physicians.
The United States and Canadian Academy of Pathology designates this Other activity (enduring materials and internet live activity) for a maximum of 2 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Live Q&A Session: Tue, March 16, 11:00 AM – 11:30 AM PT
A 63-year-old man with a history of mixed hyperlipidemia and gallstones underwent cholecystectomy for recurrent episodes of pancreatitis. A follow-up computed tomography (CT) scan revealed an interval increase in the size of an ill-defined, mass-like lesion in the pancreatic head with peripheral enhancement and central necrosis, concerning for malignancy (Figure 1). Endoscopic ultrasound with fine needle aspiration documented a solid/cystic mass and acinar cells on cytology. He underwent pancreaticoduodenectomy.
See figures and answer here: Case 2: Quarter 2, 2021
MESSAGE FROM THE PRESIDENT
Pancreatobiliary Pathology Society (PBPS) Members,
We will all remember 2020 as a year filled with challenges and new ways of doing things, and many of our modified processes are spilling into 2021 as well. With the upcoming USCAP meeting being virtual, we have been working to prepare a compelling agenda for our PBPS Companion Meeting, and I am pleased to report that we have a very fine program devoted to the topic of pancreatitis. Our speakers will include Dr. Barbara Centeno (Cytopathology of inflammatory lesions of the pancreatobiliary tree), Dr. Vikram Deshpande (IgG4-related (autoimmune) pancreatitis), Dr. Günter Klöppel (Acute/alcoholic pancreatitis) and Dr. Giuseppe Zamboni (Paraduodenal pancreatitis). The lectures will be prerecorded, so you can listen to them any time after they go live on March 1. Because of the modified format, the session will only be 90 minutes this year. Please access the talks via the USCAP website. There will be a 30 minute live question and answer session, hosted by Michelle Reid, PBPS Education Committee Chair, on Tuesday, March 16 at 2:00 PM Eastern time. You can enter your questions on-line as well, and Michelle will review them with the speakers. We hope this will be a highly interactive Q&A session, and that the virtual format will allow even more participants to hear these lectures.
I also want to remind everyone about the PBPS Abstract Award competition. Our PBPS Education Committee will select the winning abstract for 2021, and the first author will receive a $500 prize. All applications should be submitted no later than 2/15/2021. Please see the PBPS website for details.
In other news, we have recently revamped our Journal Watch feature, kindly edited by Daniela Allende, PBPS Chair of Journal Watch Subcommittee – please keep an eye on our website for updates about excellent publications related to pancreatobiliary pathology.
We truly regret that we cannot gather in person this year – one of the hardest things about the pandemic of course is the restriction on seeing family, friends, and colleagues – but there is a light at the end of the tunnel, and we will look forward to future meetings when we can gather again to share our interests and catch up on our professional lives!
David Klimstra, Pancreatobiliary Pathology Society President
Accepting Applications for PBPS Abstract Award in USCAP 2021
Dear members of the PBPS,
Happy new year!
The PBPS is now accepting applications for this year’s PBPS Abstract Award. This award will go to a pathology trainee with an abstract (poster/platform) in pancreatobiliary pathology presented at the 2021 annual USCAP meeting. Submitted abstracts will be evaluated for originality, scientific merit and presentation, and the winner will receive a $500 prize. At least one author should be a PBPS member. Trainees are strongly encouraged to apply.
The deadline for submission of Award applications is February, 2021.
Please email your completed abstract in Word format along with the information below to the education committee chair Dr. Michelle Reid (email@example.com).
Date/Time of Presentation:
Poster Number (if applicable):
A 73-year-old female with a history of monoclonal gammopathy of undetermined significance (MGUS) and small fiber peripheral neuropathy was found to have elevated transaminases and alkaline phosphatase (ALP) – ALT 54 U/L (normal range 15-41), AST 66 U/L (normal range 14-54), ALP 322 U/L (normal range 38-126) on routine laboratory testing. Total bilirubin was within normal limits (0.3 mg/dL), and gamma-glutamyl transferase was not performed. Abdominal CT showed diffuse thickening and enhancement of the extrahepatic and central intrahepatic biliary tree with associated areas of narrowing as well as mild intrahepatic biliary ductal dilation. During ERCP, mucus was seen extruding from a gaping papilla, thus clinically a pancreatic main duct intraductal papillary mucinous neoplasm (IPMN) was considered. Bile duct brushing cytology showed atypical cells, which were favored to represent a reactive process. Whipple resection was performed for the suspected IPMN. After the Whipple procedure, she experienced an initial improvement in laboratory values. A rheumatologic evaluation was negative, including autoimmune (ANA, ANCA, SSA, SSB, anti-dsDNA, and anti-mitochondrial antibodies), infectious (viral hepatitis, HIV), and immunoglobulin (SPEP, quantitative immunoglobulins, including repeated IgG4) testing. Since her initial improvement, follow-up MRI showed new and worsening areas of stricture and continued thickening and enhancement of her biliary tree. Since optimizing her immunosuppressive regimen, her disease has remained stable.
See figures and answer here: Case #1: Quarter 1, 2021
Pancreatic Cancer Awareness Month
This month, with so many global issues in front of us, I want to remind everyone that November is Pancreatic Cancer Awareness Month. Pancreatic cancer has been in the national consciousness this year, in part due to well-known figures who have been affected, but we also draw greater awareness to the disease through Pancreatic Cancer Awareness Month, to urge private and public agencies to extend more funding to study this disease and help researchers search for a cure and improve the lives of those affected. This year, over 56,000 people in the United States will be diagnosed with pancreatic cancer, and many more around the world will be affected. Recognition of the growing prevalence of pancreatic cancer, with the help of foundations and organizations like the Pancreatobiliary Pathology Society, can help direct resources towards research and clinical care efforts. Thursday, November 19 is World Pancreatic Cancer Day – an even more focused opportunity to recognize this disease and the numerous efforts to improve the care of those affected. Please remember to “wear purple” and spread the word that we are redoubling our efforts, so that the impetus to address pancreatic cancer is also felt throughout the year and reflected in renewed energy and enthusiasm for research collaboration and knowledge sharing. Pancreatobiliary pathologists are charged with establishing the diagnosis of pancreatic cancer, and surely we should be leading advocacy efforts as well!
David Klimstra, President
Pancreatobiliary Pathology Society
A 58-year-old woman with no significant past medical history developed left abdominal pain. An abdominal MRI showed an irregular enhancing 4.5 x 4.0 cm pancreatic tail mass that was inseparable from vessels in the splenic hilum. Endoscopic ultrasound-guided fine-needle aspiration showed rare malignant cells, favoring adenocarcinoma. The patient subsequently underwent neoadjuvant therapy with Gemcitabine/Abraxane followed by a distal pancreatectomy, splenectomy, partial omentectomy and removal of surrounding lymph nodes.
See figures and answer here: Case 4: Quarter 4, 2020
A 38-year-old female with a history of hypertension presented to the emergency department with complaints of nausea, vomiting, and back pain. MRI showed a T1 hypointense, T2 hyperintense, nonenchancing cystic lesion at the tail of the pancreas, which caused mass effect upon the spleen and stomach. A distal pancreatectomy was subsequently performed. The patient is currently being followed with no evidence of recurrence or malignant transformation.
See figures and answer here: Case 3: Quarter 3, 2020
I am sad to share news of the death on July 7 in Milan, Italy of Dr. Juan Rosai.
Dr. Rosai was clearly one of the most influential figures in surgical pathology in the last 50 years, whose broad diagnostic expertise was recognized worldwide. For much of his career, he served as a consultant to the international pathology community, providing expert second opinions and making enormous contributions to direct patient care. As a researcher, Dr. Rosai was best known for his work on neoplasms of the thyroid, thymus, and vascular system, but essentially there is no subspecialty area that did not receive his investigative attention. In fact, he wrote many papers on pancreatic neoplasms, and it was his encouragement of me to pursue a case of pancreatic acinar cell carcinoma that led me to the field of pancreatic pathology. Dr. Rosai was among the first to embrace technologies like electron microscopy, immunohistochemistry, and molecular biology to enhance pathologic diagnosis. He was also one of the first pathology leaders to promote digital pathology and predicted the field’s evolution from microscopic to digital pathology many years before it occurred, and he pushed for subspecialization of academic pathology years before it became commonplace – ironic, given that he himself was the quintessential generalist. But perhaps his most lasting contributions were made as a mentor and teacher, roles he took on with great enthusiasm. He fostered the careers of countless trainees, many of whom are now in leadership positions around the world. Recitation of his numerous achievements, awards, and honors can await more formal tributes that will appear in time, but no one can doubt that Juan Rosai achieved as much as any individual can in our field, and his influence has been felt across all subspecialties. A world-renowned surgical pathologist, as well as a treasured friend to many, Dr. Rosai’s generous spirit and ability to build consensus are as much a part of his legacy as his unparalleled expertise. Our thoughts are with his wife, Dr. Maria Luisa Carcangiu, and his children.
President, Pancreatobiliary Pathology Society
PANCREATOBILIARY PATHOLOGY SOCIETY’S SPECIAL SECTION IN Archives of Pathology and Laboratory Medicine
Dear Pancreatobiliary Pathology Society Members
I am writing to draw your attention to the newly released Arch Pathol Lab Med (https://archivesofpathology.org/toc/arpa/144/7) which includes a Special Section containing review articles on the topics we presented at our 2019 USCAP Companion Meeting session. You will find comprehensive and authoritative reviews written by our speakers, Drs. Laura Wood, Laura Tang, Stefano La Rosa, and Huamin Wang, along with selected collaborators. We are particularly pleased and grateful to the Editors of Archives, Drs. Philip Cagle and Donna Hansel, for agreeing to publish a Special Section based on our meeting, and to Managing Editor Katie Giesen, whose assistance was tremendously helpful during the process.
I am also happy to report that we will be publishing a second installment based on the presentations at the 2020 USCAP Companion Meeting, so stayed tuned. Thanks to all who participated in authoring, reviewing, and publishing these reviews, and I hope you all enjoy reading them.
On behalf of the Executive and Education Committees
Pancreatobiliary Pathology Society
A 24-year-old female presented to the emergency department with severe left-sided abdominal pain. CT abdomen/pelvis showed a heterogeneous mass in the tail of the pancreas with multiple metastatic liver lesions and lymphadenopathy. Liver lesion biopsies were attempted and yielded necrotic debris with outlines of atypical cells that were positive for pancytokeratin (AE1/AE3). The patient next underwent a distal pancreatectomy.
See figures and answer here: Case 2: Quarter 2, 2020
USCAP 2020: PANCREATOBILIARY PATHOLOGY COMPANION SOCIETY HANDOUTS
Cystic and Intraductal Neoplasms of the Pancreatobiliary Tract
Martha Bishop Pitman, Deepti Dhall
Pancreatobiliary Pathology Society Best Abstract Award of USCAP2020 goes to:
Julia R. Naso, MD/PhD
University of British Columbia
Association of Inflammatory Cell Infiltrates with Signatures of Immunogenicity in Pancreatic Adenocarcinoma
Dear Pancreatobiliary Pathology Society Members,
We are gearing up for the annual USCAP meeting! Our Companion Society session will be held on Saturday, February 29th from 7-10 pm in room LACC 502-A. Our annual Business Meeting will immediately follow. This year is the end of the two-year terms for the Executive Committee so we will be presenting the slate for President, Vice President and Secretary Treasurer. Please attend and cast your votes! Also, nominations have been submitted for the PBPath Society Abstract Award and the winner will be announced at the Business Meeting.
Our society has been extremely productive over the past several months. The creation of an excellent program for the Companion Society by our Education Committee is only one of several accomplishments. I am excited to inform everyone that Archives of Pathology and Laboratory Medicine is going to publish review articles sponsored by the PBPath Society. These articles are based on the lectures that were given during our Companion Society Meeting at USCAP 2019. Please keep an eye out for these publications. Our Case of the Quarter Subcommittee remains active and has been providing educational cases for all members to tackle; this past fall, we welcomed 4 new members to the subcommittee: Deyali Chatterjee, Goo Lee, Yue Xue and Zhaohai Yang. Our bimonthly Journal Watch nicely highlights pertinent publications involving the pancreatobiliary tract.
And there is more good news. Because of Serdar Balci’s web-based knowledge and dedication to the society, the Membership/Website Committee, along with the Executive Committee, have appointed Serdar Balci as the official Webmaster for the society – congratulations Serdar on this well-deserved appointment! The PBPath Society is also now accepting ads for job and fellowship postings. The Working Groups have been productive as well: The Cytology group is wrapping-up a multi-institutional study assessing the minimal number of tumor cells required for Ki67 index calculation on pancreas FNA samples using corresponding resections as the gold standard for comparison, and the Neoadjuvant group presented their data at the 2019 USCAP Annual Meeting and is planning to write a consensus paper based on the group’s work. This past fall, PBPath Society members also participated in the ASCP, CAP and European Congress of Pathology annual meetings. Most recently, we’ve been asked to provide input on the ICCR’s draft dataset on carcinoma of the exocrine pancreas (please check your emails as the deadline is February 14th).
Our society continues to be a success because of you, its members! I would like to recognize the following members who continuously contribute time and effort to our society: Olca Basturk, for organizing another stellar USCAP Companion Society session; Serdar Balci for publishing the bimonthly journal watch; Mabel Ko for managing our website and the members of the Executive Committee, Grace Kim, David Klimstra, David Lewin, Volkan Adsay, and Olca Basturk, for keeping everything on track and in order.
The PBPath Society is an international organization that strives to improve the clinical practice of pancreatobiliary pathology by providing an environment of team work and cooperation. As my Presidency comes to an end, it amazes me how much we have accomplished over the past 2 years. None of what we now have would have been possible without such collegial, friendly, and motivated members. I am so happy and so proud that I had the chance to serve as the President of this great society.
– Alyssa M. Krasinskas, MD
Happy New Year,
Our latest Journal Watch has just been posted to the PBPS website http://pbpath.org/journal-watch/.
Please share with your colleagues, fellows, and residents.
Pancreatobiliary Pathology Society Education Committee
World Pancreatic Cancer Day
November is the Pancreatic Cancer Awareness month and November 21st is World Pancreatic Cancer day.
We, the Pancreatobiliary Pathology Society, support the mission to raise awareness and inspire action on this day.
We send our support to the survivors, their families and to everyone who has lost a loved one to this deadly disease. We also reiterate our dedication to improve the clinical practice and management of pancreatic cancer and to foster tissue-based research.
Spread the word! #WPCD or #worldpancreaticcancerday