2024 USCAP Meeting

Pancreatobiliary Pathology Society USCAP Companion Meeting 2024

Thank you for attending our companion meeting at USCAP 2024! A summary of the program is below; PDF versions of the presentations can also be downloaded from the links below.

Perspectives on Neuroendocrine and Mixed Neuroendocrine Neoplasms of the Pancreas

The Pancreatobiliary Pathology Society (PBPS) Executive Committee members and Education Committee members determined the title, content and speakers for this companion meeting.

The spectrum of pancreatic neuroendocrine neoplasms, including well differentiated neuroendocrine tumors, neuroendocrine carcinomas, and mixed neuroendocrine neoplasms, includes a range of diagnostically challenging entities with widely varying prognostic and therapeutic implications.  Recent work including genomic characterization has refined the distinction of well versus poorly differentiated neuroendocrine neoplasms but confusion remains about grading and the use of biomarkers to refine the diagnosis.  Rare neoplasms with both neuroendocrine and non-neuroendocrine (ductal or acinar) differentiation have been collected under the general category of mixed neuroendocrine-non-neuroendocrine neoplasm (MiNEN), but the definition of MiNEN remains confusing, as does the distinction among the specific diagnosis encompassed within this category  (such as mixed acinar neuroendocrine carcinoma and mixed ductal neuroendocrine carcinoma).  The concept of “amphicrine” carcinoma also exists and adds further confusion for pathologists. This course will provide the latest information on the 2022 WHO classification of neuroendocrine neoplasms, the diagnostic approach and immunohistochemical markers for routine practice, the molecular pathogenesis and clinical implications of these rare entities. This course will also cover the cytomorphologic variants of well-differentiated neuroendocrine tumors. Participants have repeatedly expressed how beneficial the interactive round table discussions (formerly known as “Pancreatobiliary Pathology Luncheons”) were prior to the PBPS formally becoming a society. To reimagine this in a larger forum, a round table section will be incorporated and hosted by Dr. Mari Mino-Kenudson and Dr. Atsuko Kasajima with all speakers participating. The speaker selection and topics covered will address the new updates and challenges associated with the diagnosis of these unusual and challenging entities, based on speaker expertise, and will provide attendees with updates on best practices.

Course Learning Objectives: 
Upon completion of this educational activity, the learner will be able to:

  • Learn the diagnostic approaches and useful ancillary studies in the differential diagnosis of MiNEN
  • Unravel the concepts related to pathogenesis and molecular diagnostics and apply these to the diagnosis of MiNEN and distinction from mimics.
  • Learn the cytomorphologic variants of well differentiated neuroendocrine tumors and their diagnostic and prognostic significance.
  • Gain knowledge regarding update on the grading and differentiation of pancreatic neuroendocrine neoplasms.
Grade Versus Differentiation of Pancreatic Neuroendocrine Neoplasms

Guido Rindi, MD, PhD, Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Università Cattolica del Sacro Cuore
Grade Versus Differentiation of Pancreatic Neuroendocrine Neoplasms

Mixed Neuroendocrine Non-neuroendocrine Neoplasms: Unraveling the Concept and Applying it to Clinical Practice

David S. Klimstra, MD. Paige.AI. Middletown, NY, United States
Mixed Neuroendocrine Non-neuroendocrine Neoplasms Unraveling the Concept and Applying it to Clinical Practice

Well-Differentiated Neuroendocrine Tumor: Does Cytomorphologic Variant Matter?

Michelle D. Reid, MD, MSc. Emory University Hospital. Decatur, GA, United States
Well-Differentiated Neuroendocrine Tumor- Does Cytomorphologic Variant Matter?

 Session Chairs

Atsuko Kasajima, MD, PhD, Klinikum Rechts der Isar, Technical University Munich


Mari Mino-Kenudson, MD, Massachusetts General Hospital, Harvard Medical School

United States